Electric Literature of 1805-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(2) To a solution of the compound (440 mg) obtained in Example 131-(1) in tetrahydrofuran (10 ml,), 3,4-dichlorobenzyl alcohol (354 mg) and N,N-diisopropyl ethyl amine (0.680 ml) were added, and the mixed solution was refluxed for eight hours. Furthermore, 3,4-dichlorobenzyl alcohol (354 mg) was added thereto, and the resulting solution was refluxed for eight hours. The solution was returned to room temperature, and ethyl acetate was added thereto. The resulting solution was washed with water, and then washed with a saturated saline solution. The organic layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to remove the solvent. The resulting crude product was purified by column chromatography (neutral OH type silica gel, ethyl acetate In-hexane = 0 to 50%) to give methyl (1-{[4-({[(3,4-dichlorobenzyl)oxy]carbonyl}amino)phenyl]carbonyl}isoquinolin-4-yl) acetate (280 mg) as a pale yellow amorphous substance. 1H NMR (600 MHz, CHLOROFORM-d) d ppm 3.73 (s, 3H), 4.11 (s, 2 H), 5.15 (s, 2H), 6.99 (br. s., 1H), 7.20 – 8.25 (m, 11H), 8.51 (s, 1H)
According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; EP2377851; (2011); A1;,
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