Magnetic-bioluminescent-nanoliposomes for ultrasensitive and portable detection of protein biomarkers in blood was written by Liu, Peng;Fang, Xueen;Cao, Hongmei;Gu, Mingli;Kong, Jilie;Deng, Anmei. And the article was included in Analytica Chimica Acta in 2018.Category: alcohols-buliding-blocks The following contents are mentioned in the article:
Protein biomarkers play an important role in the diagnosis and treatment of disease. Herein, the authors report an ultrasensitive magnetic-bioluminescent-nanoliposome based technique using a portable ATP luminometer for the point-of-care testing (POCT) of protein biomarkers in blood. The authors use alpha-fetoprotein (AFP, a protein biomarker associated with hepatocellular carcinoma) as a model protein. The bioluminescent nanoliposomes conjugated to magnetic particles (LBM) enabled target protein capture, isolation and detection. In this assay, the authors use a portable magnetic bead separation pen to simplify the steps. The output RLUs (relative light units) had a linear correlation with AFP concentration between 0.05 and 1000ng/mL, with a limit of detection of 0.016ng/mL. The authors’ LBM assay for AFP based on the portable luminometer exhibited high specificity for AFP, with no cross-reactivity with other proteins tested at 25ng/mL. Forty clin. samples (twenty AFP pos. and twenty AFP neg.) were tested by the LBM assay, and the results were in good agreement with those determined by electrochemiluminescence, with relative deviations of <10%. The successful application of magnetic-bioluminescent-nanoliposomes with a portable ATP luminometer system to detect protein biomarkers in blood has opened a new avenue for biomarker testing. Thus, the authors’ LBM assay holds great potential as a POCT assay for use in clin. diagnostics. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Category: alcohols-buliding-blocks).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts