Tripathi, Shashank published the artcileConstruction of Highly Functionalized Piperazinones via Post-Ugi Cyclization and Diastereoselective Nucleophilic Addition, Formula: C8H19NO2, the publication is Journal of Organic Chemistry (2020), 85(11), 6910-6923, database is CAplus and MEDLINE.
Aminals were prepared by Ugi multicomponent cyclocondensation reactions of 2-aminoacetaldehyde di-Me acetal, aldehydes or ketones such as 3-indolecarboxaldehyde, carboxylic acids such as benzoic acid, and isocyanides such as benzyl isocyanide. In the presence of BF3·Et2O in CH2Cl2, the aminals underwent (diastereoselective) substitution reactions with nucleophiles such as Me3SiR [R = H2C:CHCH2, NC, N3, OCPh(:CH2)], triethylsilane, or N-methylindole to yield piperazinones such as I (X = Y = O). Ugi reactions with aminoaldehyde acetals with longer carbon chains yielded only acyclic products. I (X = Y = H2) was prepared as a dragmacidin C analog, while two piperazinones were used to prepare praziquantel analogs.
Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H10S, Formula: C8H19NO2.
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