Silva-Santos, A. Rita published the artcileSeparation of plasmid DNA topoisomers by multimodal chromatography, Category: alcohols-buliding-blocks, the publication is Analytical Biochemistry (2016), 68-70, database is CAplus and MEDLINE.
The ability to analyze the distribution of topoisomers in a plasmid DNA sample is important when evaluating the quality of preparations intended for gene therapy and DNA vaccination or when performing biochem. studies on the action of topoisomerases and gyrases. Here, the authors describe the separation of supercoiled (s.c.) and open circular (oc) topoisomers by multimodal chromatog. A medium modified with the ligand N-benzyl-N-Me ethanolamine and an elution scheme with increasing NaCl concentration were used to accomplish the baseline separation of s.c. and oc plasmid. The utility of the method is demonstrated by quantitating topoisomers in a purified plasmid sample.
Analytical Biochemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H16Br3N, Category: alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts