de Gracia Lux, Caroline published the artcileControlled degradation and release of polymer based nanoparticles, Quality Control of 25240-59-9, the publication is PMSE Preprints (2012), No pp. given, database is CAplus.
Polymer based nano and microparticles have recently received much interest for their ability both to encapsulate a therapeutic and release a payload on demand, in response to stimuli such as removal of a protecting group, pH, light and oxidative conditions. Upon exposure to specific conditions, these materials undergo reactions which degrade them in a very controlled manner. This paper presents controlled degradation and release studies from two new polymeric nanoparticles. First we use oxidative conditions to trigger the degradation of H2O2 bioresponsive polymeric nanoparticles. Then, using another approach, we exploit light sensitive end-cap groups to trigger the disassembly of a linear self-immolative material. Encapsulation of drugs could provide improved pharmacokinetics as they would be protected from the physiol. environment. Selected release could also allow lower drug loading through effective site delivery.
PMSE Preprints published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Quality Control of 25240-59-9.
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https://en.wikipedia.org/wiki/Alcohol,
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