Storz, Michael P. published the artcileFrom in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Organic & Biomolecular Chemistry (2014), 12(32), 6094-6104, database is CAplus and MEDLINE.
Recent studies have shown that compounds based on a (2-nitrophenyl)methanol scaffold are promising inhibitors of PqsD, a key enzyme of signal mol. biosynthesis in the cell-to-cell communication of Pseudomonas aeruginosa. The most promising mol. displayed anti-biofilm activity and a tight-binding mode of action. Herein, the authors report on the convenient synthesis and biochem. evaluation of a comprehensive series of (2-nitrophenyl)methanol derivatives The in vitro potency of these inhibitors against recombinant PqsD as well as the effect of selected compounds on the production of the signal mols. HHQ and PQS in P. aeruginosa were examined The gathered data allowed the establishment of a structure-activity relationship, which was used to design fluorescent inhibitors, and finally, led to the discovery of (2-nitrophenyl)methanol derivatives with improved in cellulo efficacy providing new perspectives towards the application of PqsD inhibitors as anti-infectives.
Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H18O, Recommanded Product: 4,4-Diethoxybutan-1-amine.
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