Application of 17773-10-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17773-10-3, name is Choline Iodide. This compound has unique chemical properties. The synthetic route is as follows.
CORM-338; [Me3NCH2CH2OH][Mn(CO)4I2]; 450 mg (1.40 mmol) of [Mn(CO)5I] and 301 mg (1.30 mmol) of choline iodide were stirred in 15 ml of methanol at 55 C. for 36 h. (The IR Spectrum recorded after 2 h showed a significant amount of starting material remained).Following this, the solvent was removed on a rotary evaporator to give a yellow/brown ?oily? solid. This residue was dissolved in DCM, filtered, and then diethyl ether added. This precipitated out a white solid (presumably unreacted choline iodide) which was filtered off. Solvent was then removed on a rotary evaporator and the residue again dissolved in DCM. A little hexane was then added. However, this resulted in the product separating as an oil. Hence all the solvent was removed on a rotary evaporator and the resulting semi-solid residue washed twice with diethyl ether. This produced a solid product that was dried under vacuum.405 mg (0.771 mmol) of an orange/brown solid was obtained. Mr=524.96.Yield was 59%.1H NMR (CD2Cl2): delta(ppm) 3.11 (br, OH 1H), 3.35 (br, CH3 9H), 3.68 (br, CH2 2H), 4.22 (br, CH2 2H)13O NMR (CD2Cl2): delta(ppm) 55.29 (t {J=3.9 Hz}, CH3), 56.35 (CH2), 68.16 (t {J=2.8 Hz}, CH2), 213.26 (CO), 221.91 (CO)17O NMR (CD2Cl2): delta(ppm) 377.3 (CO), 379.4 (CO)55Mn NMR (CD2Cl2): delta(ppm) -863 line width 6650 HzIR (CH2Cl2) nu(cm-1): 2077 (s), 2002 (vs), 1984 (s), 1942 (s)Mass Spec (m/z): 421 (MO), 393 (M–CO), 365 (M–2CO), 337 (M–3CO), 309 (M–4CO)Elemental: MnC9H14NO5I2 found (calc) C: 20.62 (20.59), H: 2.55 (2.69), N: 2.57 (2.67), I: 48.61 (48.35); CORM-369 (Choline][Mn(CO)4I2] [3]450 mg (1.40 mmol) of Mn(CO)5I and 301 mg (01.30 mmol) of choline iodide were stirred in 15 ml of methanol at 55 C. for 36 hrs. (IR recorded after 2 hrs showed a significant amount of starting material remaining).Following this, the solvent was removed on rotary evaporator to give a yellow/brown ?oily? solid. This residue was dissolved in DCM, filtered, and then ether added. This crashed out a white solid (presumably unreacted choline iodide) which was filtered off. Solvent was then removed on rotary evaporator and the residue again dissolved in DCM. A little hexane was then added. However, this resulted in the product crashing out as an oil. Hence all the solvent was removed on rotary evaporator and the resulting semi-solid residue washed twice with ether. This produced a solid product that was dried under vacuum.405 mg of an orange/brown solid was obtained. Yield was 59.3%.1H NMR (CD2Cl2): delta(ppm) 3.35 (br, NMe3), 3.69 (br, CH2), 4.18 (br, CH2)13C NMR (CD2Cl2): delta(ppm) 54.0 (NMe3), 56.6 (CH2), 68.5 (CH2), 211.6 (CO), 219.8 (CO),IR (CH2Cl2) nu(cm-1): 2092 (w), 2015 (vs), 1989 (s), 1943 (s)Mass Spec (m/z): 215 (M–4CO) (1:2:1 ratio of peaks observed, i.e. 79Br/81Br).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17773-10-3, Choline Iodide.
Reference:
Patent; Motterlini, Roberto Angelo; Mann, Brian Ernest; Scapens, David Alistair; US2010/105770; (2010); A1;,
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