Adding a certain compound to certain chemical reactions, such as: 100751-63-1, 6-Bromo-2-naphthylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 100751-63-1, blongs to alcohols-buliding-blocks compound. SDS of cas: 100751-63-1
A mixture of the product from Example 1A (0.119 g, 0.50 mmol), 4 cyanophenylboronic acid (0.088 g, 0.60 mmol, 1.2 equiv.), PdCl2(PPh3)2 (7 mg, 0.001 mmol, 0.020 equiv.) and K3PO4H2O (288 mg, 1.5 mmol, 3.0 equiv.) in isopropanol (10 ML) and distilled water (4 ML) was stirred at 50 C. under a dry nitrogen atmosphere for 1.5 hr.The reaction mixture was cooled to room temperature then concentrated under reduced pressure.The residue was partitioned between ethyl acetate and saturated aqueous NH4Cl. The organic layer was dried (MgSO4), and filtered.The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (65:35 hexane/ethyl acetate).Fractions containing product were combined and concentrated under reduced pressure to provide the product as a white solid (95 mg, 73% yield). M.p. 174.1-175.5 C. 1H NMR (CDCl3, 300 MHz) delta 8.06 (d, J=2 Hz, 1H), 7.97-7.70 (m, 8H), 7.54 (dd, J=2, 12 Hz, 1H), 4.90 (dbr, J=6 Hz, 2H), 1.78 (tbr, J=6 Hz, 1H). MS (DCl-NH3) [M+NH4]+ at 277, [M+NH4 NH3]+ at 294.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,100751-63-1, 6-Bromo-2-naphthylmethanol, and friends who are interested can also refer to it.
Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.; US2004/92521; (2004); A1;,
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