Synthetic Route of 60666-70-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol. A new synthetic method of this compound is introduced below.
General procedure: A mixture of64(1.075g, 5.5mmol), 1-bromo-4-chlorobenzene (1.03g, 5.4mmol), Cs2CO3(2.28g, 7mmol) and BINAP (0.05 equiv) in toluene (60mL) was purged with N2, Pd(OAc)2(110mg, 0.22mmol) was added and the mixture was stirred under reflux for 16h, then cooled, diluted with EtOAc, filtered and evaporated. The residue was chromatographed on silica gel, with EtOAc/CH2Cl2(2:1) eluting24(0.62g. 37percent)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,60666-70-8, (2-Bromo-5-chlorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Flanagan, Jack U.; Atwell, Graham J.; Heinrich, Daniel M.; Brooke, Darby G.; Silva, Shevan; Rigoreau, Laurent J.M.; Trivier, Elisabeth; Turnbull, Andrew P.; Raynham, Tony; Jamieson, Stephen M.F.; Denny, William A.; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 967 – 977;,
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