Adding a certain compound to certain chemical reactions, such as: 115-20-8, Trichloroethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 115-20-8, blongs to alcohols-buliding-blocks compound. 115-20-8
General procedure: 3-Hydroxy-2-((S)-1-phenylethyl)isoindolin-1-one 1 (150 mg, 0.592 mmol, Entries 1-3, Table 1) or (100 mg, 0.395 mmol, (Entries 4-11, Table 1) was dissolved in dichloromethane (3.0 mL) under an inert atmosphere (N2) while stirring followed by the addition diethylaminosulfur trifluoride (DAST, 240 L, 1.776 mmol, 3 eq). Stirring was continued overnight (16 hr) and the alcohol (10 or 5 eq) was added and stirring was continued until the reaction was complete as indicated by TLC (4-8 hr). The crude reaction mixture was directly submitted to gravity-column chromatography and the entire series of products were eluted with hexane/ethyl acetate, 4:1. Combination and concentration of the individual fractions gave the pure products detailed in Table 1.
With the rapid development of chemical substances, we look forward to future research findings about 115-20-8.
Reference:
Article; Ronnebaum, Jarrid M.; Luzzio, Frederick A.; Arkivoc; vol. 2019; 5; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts