As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C7H7BrO
Step 1 c’: Synthesis of (4′-(Trifluoromethyl)-[1 ,1 ‘-biphenyl]-3-yl)methanol To a solution of 3-bromo benzyl alcohol (0.1 g, 0.53 mM) and 4- (trifluoromethyl)phenyl)boronic acid (0.121 g, 0.64 mM), DMF/water (8:1 ), Na2C03 (0.142 g, 1 .33 mM) and PdCI2(PPh3)2 (0.010 mM) were added. The reaction mixture was heated in a microwave at 1 10 ¡ãC for 6 min. The reaction mixture was quenched with water and extracted with ethyl acetate (3×10 ml). The organic layer was washed with brine, dried over Na2S04 and concentrated to obtain a crude product, which was purified by column chromatography (silica gel, 100-200 mesh, eluted with 15percent ethyl acetate in petroleum ether) to afford the title compound (4’-(trifluoromethyl)-[1 ,1 ‘- biphenyl]-3-yl)methanol as a colorless oil. Yield: 0.108 g( 80percent);1H NMR (DMSO-d6, 300 MHz): delta 7.91 (d, J=8.1 Hz, 2 H), 7.84-7.82 (m, 3 H), 7.70 (m, 1 H), 7.50-7.48 (m, 2H), 5.30 (t, J = 5.7Hz, 1 H, OH), 4.60 (d, J=5.7 Hz, 2 H); MS: m/z 275 (M+Na).
With the rapid development of chemical substances, we look forward to future research findings about 15852-73-0.
Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; MAHAJAN, Vishal, Ashok; SAWARGAVE, Sangameshwar, Prabhakar; WO2013/128378; (2013); A1;,
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