Development of an immunochromatographic test for the detection of Mycoplasma pneumoniae GroES antigen was written by Matsui, Hidehito;Sugimura, Makoto;Inoue-Tsuda, Megumi;Iwabuchi, Kazuya;Hanaki, Hideaki. And the article was included in Journal of Microbiological Methods in 2021.COA of Formula: C9H18O5S The following contents are mentioned in the article:
Mycoplasma pneumoniae frequently causes community-acquired pneumonia in children; β-lactam antibiotics are ineffective against this bacterium because of its lack of a cell wall. Hence, a rapid and simple detection method is required to ensure appropriate treatment. In this study, we developed a rapid and simple immunochromatog.-based detection method using monoclonal antibodies that react with the co-chaperone GroES of M. pneumoniae. Mice were immunized with recombinant GroES, and hybridoma cells producing anti-GroES monoclonal antibodies were established. For the development of the immunochromatog. test, antibody pairs with superior reactivity and specificity were selected. The developed immunochromatog. test could detect 0.1 ng/mL of recombinant GroES within 20 min. Moreover, no cross-reaction was observed with other microorganisms, including six Mycoplasma species, 20 other bacterial species, and one yeast species. Macrolide-resistant and -susceptible M. pneumoniae clin. isolates were detected at approx. 104 to 105 colony-forming units/mL. The study indicates that immunochromatog. tests targeting GroES are useful for rapid and simple detection of M. pneumoniae. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1COA of Formula: C9H18O5S).
(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C9H18O5S
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