Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., name: 2-(Diethylamino)ethanol
Into a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device were placed 12.8 g (0.1 mol) of adipic anhydride, 35.1 g (0.3 mol) of N, N-diethylaminoethanol,0.8gTitanyl sulfate, 20 mlXylene, stirring heated to 145 C refluxing reaction 3h, until the separation of 1.8g (0.1mol) water, remove the catalyst filter (direct reuse), the filtrate into another 250ml three bottles, vacuum distillation of solvent ), An excess amount of diethylaminoethanol (used for recovery), and a low boiling point substance were added, and 3.0 g of activated clay was added thereto. The mixture was stirred for 30 minutes, and the temperature was lowered to 80 C or less, and filtered to obtain a yellow oily liquid bisdiethylaminoethyl adipate 31.34 G, and the yield was 91.1%. And then adipic acid bis diethylamino ethanol ester and two times the citric acid mixed heated to 120 C, the citric acid after melting, stirring cooling crystallization salt, that is a white powder solid product adipic acid bis Diethylamino ethanolate citrate. Its melting point: 117 C.
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Reference:
Patent; Suzhou Institute of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Siyuan; Qiu, Yexian; (13 pag.)CN105801441; (2016); A;,
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