Synthesis, structure and SOD activity of Mn complexes with symmetric Schiff base ligands derived from pyridoxal was written by Signorella, Sandra;Daier, Veronica;Ledesma, Gabriela;Palopoli, Claudia;Back, Davi Fernando;Lang, Ernesto S.;Kopp, Cristieli Rossini;Ebani, Patricia;Pereira, Mateus Brum;Giacomelli, Cristiano;Piquini, Paulo Cesar. And the article was included in Polyhedron in 2015.Synthetic Route of C8H10ClNO3 The following contents are mentioned in the article:
This study describes the synthesis, crystal structure and antioxidant activity of Mn(III) complexes with Schiff-base ligands obtained from condensation of pyridoxal with alkyl diamines: [Mn(pyr2en)(H2O)2]Cl·4H2O, [Mn(pyr2en)(H2O)(MeOH)]Cl, [Mn(pyr2pn)(H2O)2]ClO4 and [Mn2(pyr2bn)3]·4H2O, where H2pyr2en = 1,2-bis(pyridoxylidenamino)ethane, H2pyr2pn = 1,3-bis(pyridoxylidenamino)propane and H2pyr2bn = 1,4-bis(pyridoxylidenamino)butane. The four complexes catalyze the dismutation of superoxide efficiently with IC50 values at 1.22-2.15 μM, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The length of the alkyl spacer in the diamine fragment plays a key role in the antioxidant activity of these complexes, with [Mn(pyr2pn)(H2O)2]ClO4 showing the lowest IC50 value. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Synthetic Route of C8H10ClNO3).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C8H10ClNO3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts