In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 722-92-9
To a solution of 4( 1 hydroxy-1 rifluoromethyl2,2,24ritiuoroethyl)aniline (60mg, 0.232 mmol) in CH2CI2 (2 mL) were successively added at RT N,Ndiisopropylethylamine (80 pL, 0.463 mmol) and 2chlorobenzoyl chloride (41 pL, 0.324 mmd). The mixture was stirred for 3 h and concentrated under reduce pressure. The crude residue was directly purified by cdumn chromatography on siNca gel without any workup by hexane/AcOEt (812) to obt&n 65 mg (71percent) 0 SR987 as a white powder: FTR cm1 3338. 3028, 1643, 1521, 1410; 1254. 1219, 1188, 1112, 968, 944, 826; 1H NMR (400 MHz, MeODd4) S =797 (t, J = 1.8 Hz, 1 H), 7.91 7.86 (m, I H), 7.85 7.80 (m, 2 H), 7.75 7.70 (m, 2 H),7.63 7.58 (m, I H), 7.51 (t, J 7.8 Hz, 1 H); 13C NMR (101 MHz, MeODd4) S = 167.5,141.5, 138.2, 135.9, 133.1, 131.4, 129.0 (2C), 128.9, 128.5, 127.3 (2C), 121.7 Thereare tree carbons msshg for the descdpton of SR1078. They correspond to the three carbons of the (1 hydroxy- 1 trmuoromethy2 2 ,24fiuoroethy) moety. The fluodne coupng with these carbons gkte muWpets that are very dUflcuft to see on the ?3C spectrum even with a proonged number of scans. HRMS (ES) m/z [M+H] c&cd for C16H10CF6NO2, 398.0377; found, 398.0395; Mp = 170A72C.
The synthetic route of 722-92-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; GRIFFIN, Patrick; KAMENECKA, Theodore; CHANG, Mi, Ra; DOEBELIN, Christelle; (58 pag.)WO2017/79120; (2017); A1;,
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