Li, Chuan-Hai et al. published their research in Ecotoxicology and Environmental Safety in 2021 | CAS: 620-92-8

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 620-92-8

Binding and activity of bisphenol analogues to human peroxisome proliferator-activated receptor β/δ was written by Li, Chuan-Hai;Zhang, Dong-Hui;Jiang, Li-Dan;Qi, Yuan;Guo, Liang-Hong. And the article was included in Ecotoxicology and Environmental Safety in 2021.Reference of 620-92-8 The following contents are mentioned in the article:

Several studies have indicated metabolic function disruption effects of bisphenol analogs through peroxisome proliferator-activated receptor (PPAR) alpha and gamma pathways. In the present study, we found for the first time that PPARβ/δ might be a novel cellular target of bisphenol analogs. By using the fluorescence competitive binding assay, we found seven bisphenol analogs could bind to PPARβ/δ directly, among which tetrabromobisphenol A (TBBPA, 18.38-fold) and tetrachlorobisphenol A (TCBPA, 12.06-fold) exhibited stronger binding affinity than bisphenol A (BPA). In PPARβ/δ-mediated luciferase reporter gene assay, the seven bisphenol analogs showed transcriptional activity toward PPARβ/δ. Bisphenol AF (BPAF), bisphenol F (BPF) and bisphenol B (BPB) even showed higher transcriptional activity than BPA, while TBBPA and TCBPA showed comparable activity with BPA. Moreover, in human liver HL-7702 cells, the bisphenol analogs promoted the expression of two PPARβ/δ target genes PDK4 and ANGPTL4. Mol. docking simulation indicated the binding potency of bisphenol analogs to PPARβ/δ might depend on halogenation and hydrophobicity and the transcriptional activity might depend on their binding affinity and hydrogen bond interactions. Overall, the PPARβ/δ pathway may provide a new mechanism for the metabolic function disruption of bisphenol analogs, and TBBPA and TCBPA might exert higher metabolic disruption effects than BPA via PPARβ/δ pathway. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts