Reference of 583-03-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.583-03-9, name is 1-Phenylpentan-1-ol, molecular formula is C11H16O, molecular weight is 164.24, as common compound, the synthetic route is as follows.
At room temperature, in a 50 ml round-bottom flask is sequentially added in the 1 – benzene amyl alcohol (0.164 g, 1 mmol), benzoic acid (0.183g, 1.5 mmol), NBS (0.356g, 2 mmol) and 1, 4 – dioxane (2 ml). In the 60 C stirring 1 hour, then adding DBU (0.304 g, 2 mmol), continue to reaction 4 hours (TLC detection reaction). Then, stopping the reaction, concentrated under reduced pressure, to obtain crude product. Finally petroleum ether and ethyl acetate mixed eluent flushing, rapid column chromatography (silica gel column) to obtain the corresponding product alpha – acyloxy ketone compound (yellow liquid 0.260g, yield 92%).
The chemical industry reduces the impact on the environment during synthesis 583-03-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Qufu Normal University; Wang, Hua; Wei, Wei; Zhu, Minghui; Cui, Huanhuan; (19 pag.)CN106518663; (2017); A;,
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