Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Diethylamino)ethanol
General procedure: 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carboxylate hydrochlorides 7a-7f were synthesized as described above for 6a-6e from 7 mmol of amino alcohol 5a-5f and 1.87 g (7 mmol) of acid chloride 3 in the presence of 0.7 g (7 mmol) of triethylamine. A solution of 1.3 g (5 mmol) of acid chloride 3 in 30 mL of anhydrous benzene was added with shaking to a mixture of 5 mmol of diamine 4a-4e and 0.5 g (5 mmol) of triethylamine in 50 mL of anhydrous benzene. The mixture was left to stand for 2 h at room temperature and was then refluxed for 10 h. After cooling, the mixture was treated with 3 mL of 15% aqueous sodium hydroxide with shaking, and the organic layer was separated, washed with water until neutral reaction, and dried. The solvent was distilled off, the residue was dissolved in diethyl ether, and a solution of dry HCl in diethyl ether was added. The precipitate was filtered off and recrystallized from ethanol.
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Reference:
Article; Arustamyan, Zh. S.; Markaryan; Aghekyan; Nazaryan; Hakobyan; Paronikyan; Minasyan; Russian Journal of Organic Chemistry; vol. 55; 6; (2019); p. 796 – 799; Zh. Org. Khim.; vol. 55; 6; (2019); p. 896 – 900,5;,
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