New materials for use as insect repellents was written by Smith, C. N.. And the article was included in Proceedings of the Annual Meeting, Chemical Specialties Manufacturers Association in 1950.SDS of cas: 115-84-4 The following contents are mentioned in the article:
Recent investigations of insect repellents for the U.S. Dept. of Defense have involved treatments for skin and clothing. Skin treatments in Alaska showed Pr N,N-diethylsuccinamate and dimethyl cis-bicyclo-[2.2.1]-5-heptene-2,3-dicarboxylate to be most effective against mixed populations of several species of Aedes mosquitoes. Compounds which were outstanding in clothing treatments against several species of mosquitoes included 2-butyl-2-ethyl-1,3-propanediol, N-butyl-1,2,3,6-tetrahydrophthalimide, α-butoxy-N-cyclohexylacetamide, Indalone, hexyl mandelate, Repellent 612, and dimethyl phthalate. N-butyl-, N-propyl-, and N-isopropylacetanilide, and N,N-dibutylaceto- and α-butoxy-N-cyclohexylacetamide were 90-100% effective against the lone star tick, Amblyomma americanum. Benzyl benzoate was effective against cat fleas, Ctenocephalides felis; hexyl mandelate and N-butyl- and N-prophylacetanilide were effective against rat fleas, Xenopsylla cheopis; hendecylic acid was effective against both. A mixture containing 30% each of 2-butyl-2-ethyl-1,3-propanediol, N-butylacetanilide, benzyl benzoate and 10% Tween 80 emulsifier, tested at 3.2 active ingredients/sq. ft. of cloth, was more effective against 3 species of mosquitoes than any individual repellent, was about equal to the best individual repellent against ticks, and only slightly less effective than the best against fleas; toxicity and skin-irritation tests are under way. The most practical materials for area control of chiggers are toxaphene, chlordan, and benzene hexachloride; for personal protection, benzyl benzoate. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4SDS of cas: 115-84-4).
2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 115-84-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts