In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts was written by Abellan, Alicia;Mensink-Bout, Sara M.;Garcia-Esteban, Raquel;Beneito, Andrea;Chatzi, Leda;Duarte-Salles, Talita;Fernandez, Mariana F.;Garcia-Aymerich, Judith;Granum, Berit;Iniguez, Carmen;Jaddoe, Vincent W. V.;Kannan, Kurunthachalam;Lertxundi, Aitana;Lopez-Espinosa, Maria-Jose;Philippat, Claire;Sakhi, Amrit K.;Santos, Susana;Siroux, Valerie;Sunyer, Jordi;Trasande, Leonardo;Vafeiadi, Marina;Vela-Soria, Fernando;Yang, Tiffany C.;Zabaleta, Carlos;Vrijheid, Martine;Duijts, Liesbeth;Casas, Maribel. And the article was included in Environment International in 2022.Related Products of 620-92-8 The following contents are mentioned in the article:
In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only. To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-anal. on individual participant data. Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (p-interaction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Related Products of 620-92-8).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 620-92-8
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