Effect of lipopolymer (DSPE-PEG750) on phospholipid monolayers and bilayers differing in the structure of the polar head group was written by Kowalska, Magdalena;Broniatowski, Marcin;Mach, Marzena;Plachta, Lukasz;Wydro, Pawel. And the article was included in Journal of Molecular Liquids in 2021.Product Details of 923-61-5 The following contents are mentioned in the article:
Phospholipid liposomes are the most popular kind of vesicles used in drug delivery due to their high biocompatibility with biomembranes. However, this type of liposomes show some limitations related with their short half-life in bloodstream. This problem can be resolved by the coating of their surface with the application of PEG mols. which form steric and entropic barrier, avoiding recognition of encapsulated liposomes by the reticuloendothelial system (RES). Such modification of liposomes significantly affects the physicochem. characteristics of PEGylated liposomes, which is related to the intermol. interactions between the lipopolymer mols. and the phospholipid that builds the liposome membrane. In our work we investigated the influence of the PEG-ylated lipid (DSPE-PEG750) on physicochem. properties of phospholipid monolayers and bilayers with different structure of the polar group (DPPC, DPPE, DPPS). The phospholipid monolayers were examined with the application of Langmuir monolayer technique and Brewster angle microscopy (BAM) as well as grazing incidence x-ray diffraction (GIXD). The studies performed on phospholipid bilayer systems were related to dynamic light scattering and ζ potential measurements and the experiments with the calcein release and steady-state fluorescence anisotropy of DPH. The obtained results showed that the type of polar group of phospholipid as well as the addition of PEG-ylated lipid significantly changes the mol. organization of phospholipid monolayers. Moreover, these parameters also influence the properties of phospholipid bilayers such as size, surface charge, stability and permeability. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Product Details of 923-61-5).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 923-61-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts