Structure Dependence of Pyridine and Benzene Derivatives on Interactions with Model Membranes was written by Peters, Benjamin J.;Van Cleave, Cameron;Haase, Allison A.;Hough, John Peter B.;Giffen-Kent, Keisha A.;Cardiff, Gabriel M.;Sostarecz, Audra G.;Crick, Dean C.;Crans, Debbie C.. And the article was included in Langmuir in 2018.Formula: C37H74NO8P The following contents are mentioned in the article:
Pyridine-based small-mol. drugs, vitamins, and cofactors are vital for many cellular processes, but little is known about their interactions with membrane interfaces. These specific membrane interactions of these small mols. or ions can assist in diffusion across membranes or reach a membrane bound target. This study explored how minor differences in small mols. (isoniazid, benzhydrazide, isonicotinamide, nicotinamide, picolinamide, and benzamide) can affect their interactions with model membranes. Langmuir monolayer studies of DPPC or DPPE, in the presence of the mols. listed, showed that isoniazid and isonicotinamide affected the DPPE monolayer at lower concentrations than the DPPC monolayer, demonstrating a preference for one phospholipid over the other. The Langmuir monolayer studies also suggested that nitrogen content and stereochem. of the small mol. could affect the phospholipid monolayers differently. To determine the mol. interactions of the simple N-containing aromatic pyridines with a membrane-like interface, 1H 1D NMR and 1H-1H 2D NMR techniques were utilized to obtain information about position and orientation of the mols. of interest within aerosol-OT (AOT) reverse micelles. These studies showed that all 6 of the mols. resided near the AOT sulfonate head-groups and ester linkages in similar positions, but nicotinamide and picolinamide tilted at the water-AOT interface to varying degrees. Combined, these studies demonstrate that small structural changes of small N-containing mols. can affect their specific interactions with membrane-like interfaces, and specificity toward different membrane components. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Formula: C37H74NO8P).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C37H74NO8P
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts