The Composition of Reconstituted High-Density Lipoproteins (rHDL) Dictates the Degree of rHDL Cargo- and Size-Remodeling via Direct Interactions with Endogenous Lipoproteins was written by Pedersbaek, Dennis;Kraemer, Martin Kisha;Kempen, Paul Joseph;Ashley, Jon;Braesch-Andersen, Sten;Andresen, Thomas L.;Simonsen, Jens B.. And the article was included in Bioconjugate Chemistry in 2019.Application of 923-61-5 The following contents are mentioned in the article:
The application of reconstituted high-d. lipoproteins (rHDL) as a drug-carrier has during the last decade been established as a promising approach for effective receptor-mediated drug delivery, and its ability to target tumors has recently been confirmed in a clin. trial. The rHDL mimics the endogenous HDL, which is known to be highly dynamic and undergo extensive enzyme-mediated remodulations. Hence, to reveal the physiol. rHDL stability, a thorough characterization of the dynamics of rHDL in biol. relevant environments is needed. The authors employ a size-exclusion chromatog. (SEC) method to evaluate the dynamics of discoidal rHDL in fetal bovine serum (FBS), where the authors track both the rHDL lipids (by the fluorescence from lipid-conjugated fluorophores) and apoA-I (by human apoA-I ELISA). The authors show by using lipoprotein depleted FBS and isolated lipoproteins that rHDL lipids can be transferred to endogenous lipoproteins via direct interactions in a nonenzymic process, resulting in rHDL compositional- and size-remodeling. This type of dynamics could lead to misinterpretations of fluorescence-based rHDL uptake studies due to desorption of labile lipophilic fluorophores or off-target side-effects due to desorption of incorporated drugs. Importantly, the authors show how the degree of rHDL remodeling can be controlled by the compositional design of the rHDL. Understanding the correlation between the mol. properties of the rHDL constituents and their collective dynamics is essential for improving the rHDL-based drug delivery platform. Taken together, the work highlights the need to carefully consider the compositional design of rHDL and test its stability in a biol. relevant environment, when developing rHDL for drug delivery purposes. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Application of 923-61-5).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 923-61-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts