Extended knowledge of 2,6-Dimethylheptan-4-ol

Application of 108-82-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-82-7, name is 2,6-Dimethylheptan-4-ol, molecular formula is C9H20O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General Procedure for Carbamate FormationThe desired alcohol (1.0 equiv.) was dissolved in DCM (0.3 M) in a flame-dried round- bottom flask under a nitrogen atmosphere at 00C. Pyridine (1.0 equiv.) was added followed by 2,2,2- trifluoroethylisocyanate solution (1.0 equiv., stored at -200C) added dropwise. The resulting solution was warmed to ambient temperature and stirred for two hours or until TLC showed complete consumption of the alcohol. The crude reaction was concentrated in vacuo. Flash chromatography (silica gel, DCM) provided the corresponding carbamate .; Compound 1 : Yield: 0.533 g, 97%Physical State: white solid mp: 42-43 0C Rf: 0.65 (silica gel, DCM)IR (film) Vmax: 3462, 3016, 2970, 2359, 1739, 1522, 1366, 1229, 1156 cm”11H mm (500 MHz, CDCl3) : delta 5.11-5.09 (m, 1 H) , 4.96- 4.93 (m, 1 H) , 3.79-3.74 (m, 2 H) , 1.62-1.58 (m, 2 H) , 1.48-1.46 (m, 2 H) , 1.29-1.25 (m, 2 H) , 0.90-0.88 (m, 12 H)13C NMR (125 MHz, CDCl3) : delta 156.4, 127.7-121.0 (q, J = 277 Hz) , 73.3, 44.3, 43.1-42.3 (q, J = 34 Hz) , 24.8, 23.2, 22.4HRMS (ESI) : calcd. for Ci2H22F3NO2Na [M + Na+] 292.1495, found 292.1498

According to the analysis of related databases, 108-82-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/137691; (2009); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts