Validated GC-MS method for determination of bisphenol a and its five analogues in dietary and nutritional supplements was written by Owczarek, Katarzyna;Waraksa, Emilia;Klodzinska, Ewa;Zrobok, Yaroslav;Ozimek, Mariusz;Rachon, Dominik;Kudlak, Blazej;Wasik, Andrzej;Mazerska, Zofia. And the article was included in Microchemical Journal in 2022.Synthetic Route of C13H12O2 The following contents are mentioned in the article:
Bisphenol A (BPA) and its analogs showing structural and functional similarity to BPA are commonly applied in various industrial applications and thus are becoming ubiquitous in the environment. At the same time there is increasing scientific evidence that exposure to these chems. may lead to adverse health effects in human and wildlife. In recent years dietary and nutritional supplements dedicated for athletes have become more popular and are widely used even by people who are not professionals. This study presents the development, optimization and validation of an anal. procedure for determination of six bisphenol analogs in dietary supplements using gas chromatog. – mass spectrometry technique. All validation parameters met the established acceptance criteria in accordance with international guidelines. The method was linear within the tested range of 50-1000 ng/mL, the limit of quantitation was set as the lowest calibration point 50 ng/mL, detection limit for each bisphenol was calculated as standard estimation error on the basis of the linearity testing and was in the range of 8.73-15.44 ng/mL. Method trueness, accuracy (within and between runs) and precision were also verified and were in the range of 78.8 – 100.4%, 94.3 – 103.1%,0.5 – 9.6% resp. The developed procedure was successfully applied for real samples anal., namely for fifteen sport supplements of different composition and designated for various purposes, i.e. for increasing effectiveness, promoting muscle recovery and endurance, reducing tiredness and fatigue or increasing immune ability. For the majority of samples, bisphenols were either not detected or detected at the LOD level except bisphenol A which was quantitated in few samples at LOQ level or higher (in the range 0.852-2.892 ng/mg). The field of bisphenol analogs analytics has increased in recent years due to law regulations becoming more strict, thus the development of new anal. tools for quality control of dietary products is needed and fully justified. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C13H12O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts