Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic β-Cells: Evaluation of Murine and Human In Vitro Models was written by Al-Abdulla, Ruba;Ferrero, Hilda;Soriano, Sergi;Boronat-Belda, Talia;Alonso-Magdalena, Paloma. And the article was included in International Journal of Molecular Sciences in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:
Endocrine-disrupting chems. (EDCs) are chem. substances that can interfere with the normal function of the endocrine system. EDCs are ubiquitous and can be found in a variety of consumer products such as food packaging materials, personal care and household products, plastic additives, and flame retardants. Over the last decade, the impact of EDCs on human health has been widely acknowledged as they have been associated with different endocrine diseases. Among them, a subset called metabolism-disrupting chems. (MDCs) is able to promote metabolic changes that can lead to the development of metabolic disorders such as diabetes, obesity, hepatic steatosis, and metabolic syndrome, among others. Despite this, today, there are still no definitive and standardized in vitro tools to support the metabolic risk assessment of existing and emerging MDCs for regulatory purposes. Here, we evaluated the following two different pancreatic cell-based in vitro systems: the murine pancreatic β-cell line MIN6 as well as the human pancreatic β-cell line EndoC-βH1. Both were challenged with the following range of relevant concentrations of seven well-known EDCs: (bisphenol-A (BPA), bisphenol-S (BPS), bisphenol-F (BPF), perfluorooctanesulfonic acid (PFOS), di(2-ethylhexyl) phthalate (DEHP), cadmium chloride (CdCl2), and dichlorodiphenyldichloroethylene (DDE)). The screening revealed that most of the tested chems. have detectable, deleterious effects on glucose-stimulated insulin release, insulin content, elec. activity, gene expression, and/or viability. Our data provide new mol. information on the direct effects of the selected chems. on key aspects of pancreatic β-cell function, such as the stimulus-secretion coupling and ion channel activity. In addition, we found that, in general, the sensitivity and responses were comparable to those from other in vivo studies reported in the literature. Overall, our results suggest that both systems can serve as effective tools for the rapid screening of potential MDC effects on pancreatic β-cell physiol. as well as for deciphering and better understanding the mol. mechanisms that underlie their action. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of 4,4′-Methylenediphenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts