Electric Literature of C7H7BrOIn 2019 ,《Efficient Synthesis of Quinazolinones by Transition-Metal-Free Direct Aerobic Oxidative Cascade Annulation of Alcohols with o-Aminoarylnitriles》 appeared in ChemSusChem. The author of the article were Wang, Qi; Lv, Miao; Liu, Jianping; Li, Yang; Xu, Qing; Zhang, Xu; Cao, Hongen. The article conveys some information:
A mild and atom-economic method was developed for direct and efficient synthesis of quinazolinones I (R1 = H, 5-Cl, 6-Br, 7-CH3, etc.; R2 = C6H5, naphthalen-2-yl, thiophen-2-yl, etc.) through a transition-metal-free aerobic oxidative cascade annulation reaction of widely available o-aminoarylnitriles R32-H2NC6H3CN (R3 = H, 4-CH3, 5-Br, 6-Cl, etc.) and alcs. R2CH2OH. Air could be employed as an effective oxidant under mild conditions, generating water as the only byproduct. Possibly owing to the ”cesium effect”, the water-soluble base CsOH was found to be crucial in all key steps of the reaction mechanism. Because a wide range of substrates can be used to prepare substituted quinazolinones without contamination by transition-metal residues, this method may be of interest for application in pharmaceutical synthesis. Possible reaction paths were also proposed according to control reactions. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)
(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts