In 2019,Nanoscale included an article by Zhou, Yiqun; Liyanage, Piumi Y.; Devadoss, Dinesh; Rios Guevara, Linda Rebeca; Cheng, Ling; Graham, Regina M.; Chand, Hitendra S.; Al-Youbi, Abdulrahman O.; Bashammakh, Abdulaziz S.; El-Shahawi, Mohammad S.; Leblanc, Roger M.. SDS of cas: 156-87-6. The article was titled 《Nontoxic amphiphilic carbon dots as promising drug nanocarriers across the blood-brain barrier and inhibitors of β-amyloid》. The information in the text is summarized as follows:
The blood-brain barrier (BBB) is a main obstacle for drug delivery targeting the CNS and treating Alzheimer’s disease (AD). In order to enhance the efficiency of drug delivery without harming the BBB integrity, nanoparticle-mediated drug delivery has become a popular therapeutic strategy. Carbon dots (CDs) are one of the most promising and novel nanocarriers. In this study, amphiphilic yellow-emissive CDs (Y-CDs) were synthesized with an ultrasonication-mediated methodol. using citric acid and o-phenylenediamine with a size of 3 nm that emit an excitation-independent yellow photoluminescence (PL). The content of primary amine and carboxyl groups on CDs was measured as 6.12 x 10-5 and 8.13 x 10-3 mmol mg-1, resp., indicating the potential for small-mol. drug loading through bioconjugation. Confocal image analyses revealed that Y-CDs crossed the BBB of 5-day old wild-type zebrafish, most probably by passive diffusion due to the amphiphilicity of Y-CDs. And the amphiphilicity and BBB penetration ability didn’t change when Y-CDs were coated with different hydrophilic mols. Furthermore, Y-CDs were observed to enter cells to inhibit the overexpression of human APP and β-amyloid (Aβ) which is a major factor responsible for AD pathol. Therefore, data suggest that Y-CDs have a great potential as nontoxic nanocarriers for drug delivery towards the CNS as well as a promising inhibiting agent of Aβ-related pathol. of the AD. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6SDS of cas: 156-87-6)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 156-87-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts