In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6214-44-4, name is (4-Ethoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H12O2
To a solution of (4-ethoxyphenyl)methanol (300 mg, 1.971 mmol, commercial source: Apollo SCI) and triethylamine (328 muIota_, 2.365 mmol) in Dichloromethane (15 mL) at 0C, methanesulfonyl chloride (168 muIota_, 2.168 mmol) was added dropwise. The mixture was stirred at 0 C for 3 h. Upon completion, the reaction mixture was diluted with water and DCM and extracted with DCM (2x20ml). The combined organic layers were dried over anh. MgS04 and filtered. The filtrate was concentrated under reduced pressure to obtain 4-ethoxybenzyl methanesulfonate (454 mg, 100%) This product was used without any purification in the next reaction.
The synthetic route of 6214-44-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
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