1113-21-9 , The common heterocyclic compound, 1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, molecular formula is C20H34O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[0307] The 5E, 9E, BE-geranyl geranyl acetone (1) can be prepared by reacting 6E-10E- geranyl linalool (23) with diketene (24) catalyzed by DMAP in ethyl ether to give the ester 25. The ester 25 in. the Carroll rearrangement using Al(OiPr)j at elevated temperature can afford the desired 5E, 9E, 13E-geranyl geranyl acetone (1). In another approach, the GGA ( ) can be prepared by treating geranyi linalool (23) with the Meldrurn’s acid 26 in the Carroll rearrangement using Al(QiPr) at 160 “C, Similar}’, the use of ,’er.f-buiyl acetoaeetate (27) with geranyi linalool (23) in the Carroll rearrangement can also give the desired SE, 9E. 1 E-gerany geranyi acetone (1 ).
The synthetic route of 1113-21-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; WO2014/107686; (2014); A1;,
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