In 2022,Ma, Zhuang; Zhou, Bei; Li, Xinmin; Kadam, Ravishankar G.; Gawande, Manoj B.; Petr, Martin; Zboril, Radek; Beller, Matthias; Jagadeesh, Rajenahally V. published an article in Chemical Science. The title of the article was ãReusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcoholsã?Quality Control of 3-Pyridinemethanol The author mentioned the following in the article:
A general cobalt-catalyzed N-alkylation of amines with alcs. by borrowing hydrogen methodol. to afford alkylated amines I [R = Pr-n, cyclohexyl, Ph, etc.; R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.] was reported. The optimal catalyst for this transformation was prepared by pyrolysis of a specific templated material, which was generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary and tertiary amines including N-methylamines and selected drug mols. were conveniently prepared starting from inexpensive and easily accessible alcs. and amines or ammonia. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Quality Control of 3-Pyridinemethanol)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 3-Pyridinemethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts