In 2019,ACS Omega included an article by de Fatima, Angelo; Docampo-Palacios, Maite; Alvarez-Hernandez, Anislay; Pasinetti, Giulio M.; Dixon, Richard A.. Application of 26153-38-8. The article was titled ãAn Efficient Synthesis of Deoxyrhapontigenin-3-O-β-D-glucuronide, a Brain-Targeted Derivative of Dietary Resveratrol, and Its Precursor 4′-O-Me-Resveratrolã? The information in the text is summarized as follows:
Bioactive dietary polyphenols have health benefits against a variety of disorders, but some benefits of polyphenols may be not directly related to them, but rather to their metabolites. Recently, we have identified the brain-available phenol glucuronide metabolite deoxyrhapontigenin-3-O- β-D-glucuronide (I) in perfused rat brains following sub-acute treatment with the stilbene resveratrol. However, the role of such a metabolite in the neuroprotective activity of resveratrol is not understood, in part due to the non-com. availability of I for performing biol. evaluation in animal models of Alzheimer’s disease or other neurol. disorders. Here, we describe a concise chem. synthesis of deoxyrhapontigenin-3-O- β-D-glucuronide and its precursor, 4-O-Me-resveratrol, accomplished in 4 and 6 steps with 74% and 21% overall yields, resp., starting from com. available 3,5-dihydroxybenzaldehyde. Pivotal reactions employed in the synthesis include the palladium-catalyzed C-C coupling between 3,5-di-tert-butyldiphenylsilyloxystyrene and p-iodoanisole in the presence of tributylamine and the acid-catalyzed glucuronidation between the trichloroacetimidate-activated glucuronic acid and 4-O-Me-resveratrol. In the experiment, the researchers used many compounds, for example, 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Application of 26153-38-8
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