The author of ãSynthesis and stereostructure-activity relationship of novel pyrethroids possessing two asymmetric centers on a cyclopropane ringã?were Taniguchi, Takashi; Taketomo, Yasuaki; Moriyama, Mizuki; Matsuo, Noritada; Tanabe, Yoo. And the article was published in Molecules in 2019. Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:
2-Methylcyclopropane pyrethroid insecticides bearing chiral cyanohydrin esters or chiral ethers and two asym. centers on the cyclopropane ring, e.g., I were synthesized. These compounds were designed using a “”reverse connection approach”” between the iso-Pr group in Fenvalerate, and between two di-Me groups in an Etofenprox analog (the Me, Et form), resp. These syntheses were achieved by accessible ring opening reactions of com. available (±)-, (R)-, and (S)-propylene oxides using 4-chlorobenzyl cyanide anion as the crucial step, giving good overall yield of the product with >98% ee. The insecticidal activity against the common mosquito (Culex pipiens pallens) was assessed for pairs of achiral diastereomeric rel-(1R,2S)-, rel-(1R,2R)-cyanohydrin esters, and rel-(1R,2S)-, rel-(1R,2R)-ethers; only the rel-(1R,2R)-ether was significantly effective. For the enantiomeric (1S,2S)-ether and (1R,2R)-ether, the activity was clearly centered on the (1R,2R)-ether. The present stereostructure-activity relationship revealed that, cyanohydrin esters derived from fenvalerate were unexpectedly inactive, whereas ethers derived from etofenprox were active, and apparent chiral discrimination between the (1S,2S)-ether and the (1R,2R)-ether was observed During the present synthetic study, alternative convergent syntheses of Etofenprox and novel 4-EtO-type (1S,2S)- and (1R,2R)-pyrethroids from the corresponding parent 4-Cl-type pyrethroids was also performed, by utilizing a recently-developed hydroxylation cross-coupling reaction. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)
Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.
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