In 2022,Richter, Adrian; Narula, Gagandeep; Rudolph, Ines; Seidel, Ruediger W.; Wagner, Christoph; Av-Gay, Yossef; Imming, Peter published an article in ChemMedChem. The title of the article was ãEfficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosisã?Recommanded Product: Azetidin-3-ol hydrochloride The author mentioned the following in the article:
8-Nitrobenzothiazinones (BTZs) were a promising class of antimycobacterial agents currently under investigation in clin. trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and was applicable for preparation of a wide variety of BTZ analogs. The synthetic procedure furthermore facilitates the replacement of the sulfur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogs were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay. The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: Azetidin-3-ol hydrochloride)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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