ãBio-inspired drug-dominated supramolecular nanocomplex based on low molecular weight heparin for progressive tumor therapyã?was written by Yu, Yao; Xu, Cheng; Zhen, Le; Yang, Shan; Zhou, Jianping; Yao, Jing. Recommanded Product: 3-Bromopropan-1-olThis research focused ontumor antitumor doxorubicin heparin; (KLAKLAK)(2) peptide; Anti-angiogenesis; Low molecular weight heparin; Mitochondrial damage; Supramolecular assembly. The article conveys some information:
Low mol. weight heparin (LMWH) is a natural sulfated glycosaminoglycan with the affinity to proangiogenic factors, rendering it a promising agent for tumor therapy. Inspired by DOX binding to the helix of DNA, mitochondrial damage KLA peptide derivative (mKLA) and anti-angiogenic LMWH-chrysin conjugate (LC) are constructed to simulate the double strands for doxorubicin (DOX) binding (LKD nanocomplex). Initiated and “”locked”” by DOX, mKLA and LC temporarily aggregate by π-π stacks, electrostatic and hydrophobic interactions in aqueous condition with self-amplified DOX loading (19.07 ± 1.08 wt%). During endosome-lysosome trafficking, DOX protonated by H+ could “”unlock”” the LKD nanocomplex to disassemble, which enables mKLA and DOX to damage mitochondria and nucleus DNA resp., and LMWH could also inhibit angiogenesis. Based on the strong inhibition of tumors at all stages in vivo, we hold that LKD nanocomplex provides a new opportunity based on smart construction of carbohydrate materials for clin. advanced cancer patients. In the experiment, the researchers used many compounds, for example, 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)
3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 3-Bromopropan-1-ol
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