In 2019,ACS Catalysis included an article by Corpas, Javier; Quiros, M. Teresa; Mauleon, Pablo; Gomez Arrayas, Ramon; Carretero, Juan C.. Application In Synthesis of 2-Hydroxyphenylboronic acid. The article was titled ãMetal- and Photocatalysis to Gain Regiocontrol and Stereodivergence in Hydroarylations of Unsymmetrical Dialkyl Alkynesã? The information in the text is summarized as follows:
Herein a regioselective, stereodivergent catalytic hydroarylation of unsym. dialkyl alkynes with arylboronic acids that allows highly selective access to either E- or Z- diastereoisomers of trisubstituted alkenes I (R = 4-tBuC6H4, C6H5, 5-indolyl, etc.) II (R1 = H, Me, iPr, etc.; R2 = Et, Pr, iPr, etc.) is reported. The E-selectivity is achieved through syn-carbopalladation of the Ar-Pd species followed by protodepalladation in which a 2-pyridyl sulfonyl (SO2Py) directing group enables complete control of the regioselectivity. Access to the complementary stereochem. is achieved through a tandem Pd/Ir sequence, which includes hydroarylation and E-Z photoisomerization. Lastly, facile removal of the directing group by reduction, reductive elimination, Julia-Kocienski olefination, or Cu-catalyzed C(sp3)-C(sp2) or C(sp3)-C(sp3) cross coupling, allows for the selective preparation of stereodefined olefins and dienes. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application In Synthesis of 2-Hydroxyphenylboronic acid
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts