Xu, Xianjun; Feng, Huangdi; Zhang, Xiaoyong; Song, Liangliang; Van Meervelt, Luc; Van der Eycken, Johan; Harvey, Jeremy N.; Van der Eycken, Erik V. published an article on February 11 ,2022. The article was titled 《Pd-Catalyzed Ring Restructuring of Oxazolidines with Alkenes Leading to Fused Polycyclic Indolizines》, and you may find the article in Organic Letters.Product Details of 157142-48-8 The information in the text is summarized as follows:
A palladium-catalyzed reaction of N-propargyl oxazolidines with alkenes for the synthesis of indolizidines has been developed. Through a sequential 6-exo-dig cyclization/proton transfer/[3+2] cycloaddition/cycloreversion/aromatization process, a series of fused polycyclic indolizines are obtained in moderate to good yields with high functional group tolerance. Exptl. and theor. studies suggest that the [3+2] cycloaddition/cycloreversion of the oxazolidine ring probably involves C-C and C-O bond cleavage, providing a new ring restructuring approach for the synthesis of heterocycles. The experimental process involved the reaction of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Product Details of 157142-48-8)
2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 157142-48-8
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