New downstream synthetic route of 7-Hydroxy-4-(trifluoromethyl)coumarin

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Related Products of 575-03-1 ,Some common heterocyclic compound, 575-03-1, molecular formula is C10H5F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The compounds 2a-e and 3a-e were synthesized according to the method from literature [26?28].To a solution of compound 1a-e (10.0 mmol) in acetone (30 mL), 1,2?dibromoethane or1,3-dibromopropane (30.0 mmol) and potassium carbonate (12.3 mmol) were added. The reactionmixture was stirred at 56¡ã C for 10 h, then poured into water, and extracted with ethyl acetate (30 mL x 3).The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,575-03-1, its application will become more common.

Reference:
Article; Tian, Ye; Liang, Zhen; Xu, Hang; Mou, Yanhua; Guo, Chun; Molecules; vol. 21; 6; (2016);,
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