Reference of 599-67-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.599-67-7, name is 1,1-Diphenylethanol, molecular formula is C14H14O, molecular weight is 198.26, as common compound, the synthetic route is as follows.
General procedure: The procedure is the same for solid and liquid substrates.Alcohol (1 mmol) and iodine (3 mol%) weremixed together in a 5 mL conical reactor and the reactionmixture stirred at 25 C or 55 C for various times (5 minto 192 h), progress was monitored by TLC or by 1H NMRspectroscopy. The crude reaction mixture was dilutedwith tert-butyl methyl ether, washed with an aqueoussolution of Na2S2O3, water, dried over Na2SO4 and the solventevaporated under reduced pressure. The crude reactionmixture was subjected to column chromatography orpreparative TLC using hexane or petroleum ether/tert-butylmethyl ether mixtures and pure product(s) were obtained.Conversions were determined by 1H NMR spectroscopy.The effects of reaction variables on the type oftransformation and conversions are stated in Tables andFigures. In order to obtain the information (role) of thereaction variables and structure of substrate, the data (reactiontimes with lower conversion) are presented in someTables. In the experimental section, the best reaction conditionsare named; 3 mol% of I2 were used, giving thehighest yield.
Statistics shows that 599-67-7 is playing an increasingly important role. we look forward to future research findings about 1,1-Diphenylethanol.
Reference:
Article; Jereb, Marjan; Vra?i?, Dejan; Acta Chimica Slovenica; vol. 64; 4; (2017); p. 747 – 762;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts