Related Products of 5339-85-5 ,Some common heterocyclic compound, 5339-85-5, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 49 2-(2-(2-hydroxyethyl)phenyl)isoindoline-1,3-dione; [0379] A flask containing 2-aminophenethyl alcohol (565 mg, 4.12 mmol), phthalic anhydride (641 mg, 4.32 mmol) and acetic acid (4 mL) was heated at 100 C for 1 h. The reaction mixture was poured into water (30 mL) and the solid was filtered off and the solids were washed with water. The crude was purified by flash column chromatography to afford the desired product as white solid (435 mg, 1.63 mmol, 40%). NMR: 1.79 (br s, 1H), 2.78 (t, 2H, J = 6.4 Hz), 3.81 (t, 2H, J = 6.4 Hz), 7.20 (d, 1 H, J = 8 Hz), 7.36-7.41 (m, 1H), 7.46 (d, 2H, J = 4 Hz), 7.79-7.83 (m, 2H), 7.94-7.97 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5339-85-5, 2-(2-Aminophenyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEWLINK GENETICS; MAUTINO, Mario, R.; KUMAR, Sanjeev; JAIPURI, Firoz; WALDO, Jesse; KESHARWANI, Tanay; ZHANG, Xiaoxia; WO2011/56652; (2011); A1;,
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