Reference of 889884-94-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 889884-94-0, name is 7-Fluoronaphthalen-2-ol. A new synthetic method of this compound is introduced below.
General procedure: To a stirred solution of trichloroacetimidate glycosyl donor (0.6 mmol), and 2-naphthol derivative (0.5 mmol) in anhydrous MeCN (5 mL) was added trimethylsilyl trifluoromethanesulfonate (0.05 mL) dropwise at 0 C under argon atmosphere. The mixture was stirred at r.t. for 2 h, then cooled 0 C and the reaction was quenched with triethylamine and the mixture was concentrated under reduced pressure and purified by flash column chromatography on silica gel (EtOAc/ hexane) to afford the desired glycosides.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,889884-94-0, 7-Fluoronaphthalen-2-ol, and friends who are interested can also refer to it.
Reference:
Article; Chakraborty, Soumen; Mal, Dipakranjan; Synthesis; vol. 50; 7; (2018); p. 1560 – 1568;,
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