The author of 《Highly Efficient and Robust Enantioselective Liquid-Liquid Extraction of 1,2-Amino Alcohols utilizing VAPOL- and VANOL-based Phosphoric Acid Hosts》 were Pinxterhuis, Erik B.; Gualtierotti, Jean-Baptiste; Wezenberg, Sander J.; de Vries, Johannes G.; Feringa, Ben L.. And the article was published in ChemSusChem in 2018. Synthetic Route of C9H13NO The author mentioned the following in the article:
The large-scale production of enantiopure compounds in a cost-effective and environmentally friendly manner remains one of the major challenges of modern-day chem. The resolution of racemates through enantioselective liquid-liquid extraction was developed as a suitable solution but has remained largely underused, owing to a lack of highly efficient and robust chiral hosts to mediate the process. This paucity of hosts can in part be attributed to a poor understanding of the underlying principles behind these processes hindering the design of more efficient selectors. A previously untested class of hosts, VAPOL and VANOL derived phosphoric acids, was studied in depth for the efficient enantioselective liquid-liquid extraction of 1,2-amino alcs. A systematic investigation of extraction parameters was conducted, revealing many key interactions and DFT calculations illustrate the binding modes for the 1:1 complexes that are involved in chiral recognition. The resulting, now-optimized, procedures are highly robust and easy to implement. They are also easily scalable, as demonstrated by U-tube experiments In the experiment, the researchers used 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Synthetic Route of C9H13NO)
2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Synthetic Route of C9H13NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts