With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, molecular weight is 230.1401, as common compound, the synthetic route is as follows.575-03-1
General procedure: To around bottomed flask equipped with a magnetic stir bar were added, the7-hydroxycoumarin substrate (1 equiv.), acetone (25 mL/mmol of substrate), and K2CO3 (3 equiv.). The solution wasstirred for 5 minutes at room temperature followed by addition of R3-X (1 equiv.; R3 = alkyl, X = Br or OTs.). The reaction mixture was placed under anArgon atmosphere (balloon) and stirred at reflux temperature for 16 hours atwhich point complete consumption of substrate was observed by TLC in all cases. The reaction was cooled to r.t., poured intowater, and extracted with EtOAc (x 3). The combined extracts were dried over MgSO4. The solvent was removed in vacuo and theremaining residue purified via flash chromatography over silica gel using gradient elution with EtOAc and Hexanes to yield Compounds 18-28.?
Statistics shows that 575-03-1 is playing an increasingly important role. we look forward to future research findings about 7-Hydroxy-4-(trifluoromethyl)coumarin.
Reference:
Article; Farley, Conner M.; Dibwe, Dya Fita; Ueda, Jun-Ya; Hall, Eric A.; Awale, Suresh; Magolan, Jakob; Bioorganic and Medicinal Chemistry Letters; vol. 26; 5; (2016); p. 1471 – 1474;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts