In 2016,MedChemComm included an article by Sashidhara, Koneni V.; Rao, K. Bhaskara; Sonkar, Ravi; Modukuri, Ram K.; Chhonker, Yashpal S.; Kushwaha, Pragati; Chandasana, Hardik; Khanna, A. K.; Bhatta, Rabi S.; Bhatia, Gitika; Suthar, Manish Kumar; Saxena, Jitendra Kumar; Kumar, Vikash; Siddiqi, Mohammad Imran. Recommanded Product: 153759-59-2. The article was titled 《Hybrids of coumarin-indole: design, synthesis and biological evaluation in Triton WR-1339 and high-fat diet induced hyperlipidemic rat models》. The information in the text is summarized as follows:
In this study, a series of coumarin-indole hybrids have been synthesized and evaluated for their lipid lowering activity. Preliminary biol. screening of the synthesized compounds was undertaken in an in vitro model of the HMG-CoA reductase enzyme, and the activity was confirmed in Triton WR-1339 induced hyperlipidemic rats. Among the hybrids, compound 26 was found to be the best as it significantly reduced the serum and hepatic lipid profiles in an HFD-fed hyperlipidemic rat model. The mechanism of action seems to be associated with the regulation of HMG-CoA reductase activity in the liver, which is in good agreement with binding mode studies. Compound 26 exhibited favorable pharmacokinetic behavior for its oral administration, which underscores the potential of this template as a new class of hypolipidemic agents. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Recommanded Product: 153759-59-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts