In 2019,Nature Chemistry included an article by Fawcett, Alexander; Biberger, Tobias; Aggarwal, Varinder K.. Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane. The article was titled 《Carbopalladation of C-C σ-bonds enabled by strained boronate complexes》. The information in the text is summarized as follows:
Transition-metal-catalyzed cross-coupling reactions, particularly those mediated by Pd, are some of the most broadly used chem. transformations. The fundamental reaction steps of such cross-couplings typically include oxidative addition, transmetalation, carbopalladation of a π-bond and/or reductive elimination. Herein, the authors describe an unprecedented fundamental reaction step: a C-C σ-bond carbopalladation. Specifically, an aryl Pd(II) complex interacts with a σ-bond of a strained bicyclo[1.1.0]butyl boronate complex to enable addition of the aryl Pd(II) species and an organoboronic ester substituent across a C-C σ-bond. The overall process couples readily available aryl triflates and organoboronic esters across a cyclobutane unit with total diastereocontrol. The pharmaceutically relevant 1,1,3-trisubstituted cyclobutane products are decorated with an array of modular building blocks, including a boronic ester that can be readily derivatized. In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)
4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane
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