Hurtado, Carolina Ramos; Hurtado, Gabriela Ramos; Lupeti de Cena, Gabrielle; Queiroz, Rafaela Campos; Silva, Alexandre Vieira; Diniz, Milton Faria; dos Santos, Veronica Ribeiro; Trava-Airoldi, Vladimir; da Silva Baptista, Mauricio; Tsolekile, Ncediwe; Oluwafemi, Oluwatobi Samuel; Conceicao, Katia; Tada, Dayane Batista published their research in Nanomaterials in 2021. The article was titled 《Diamond nanoparticles-porphyrin mTHPP conjugate as photosensitizing platform: cytotoxicity and antibacterial activity》.Computed Properties of C7H6O2 The article contains the following contents:
Conjugation of photosensitizers (PS) with nanoparticles has been largely used as a strategy to stabilize PS in the biol. medium resulting in photosensitizing nanoparticles of enhanced photoactivity. Herein, Meso-5, 10, 15, 20-tetrakis (3-hydroxyphenyl) phorphyryn (mTHPP) was conjugated with diamond nanoparticles (ND) by covalent bond. Nanoconjugate ND-mTHPP showed suitable stability in aqueous suspension with 58 nm of hydrodynamic diameter and Zeta potential of -23 mV. The antibacterial activity of ND-mTHPP was evaluated against Escherichia coli for different incubation times (0-24 h). The optimal activity was observed after 2 h of incubation and irradiation (660 nm; 51 J/cm2) performed right after the addition of ND-mTHPP (100 μg/mL) to the bacterial suspension. The inhibitory activity was 56% whereas ampicillin at the same conditions provided only 14% of bacterial growth inhibition. SEM images showed agglomerate of ND-mTHPP adsorbed on the bacterial cell wall, suggesting that the antimicrobial activity of ND-mTHPP was afforded by inducing membrane damage. Cytotoxicity against murine embryonic fibroblast cells (MEF) was also evaluated and ND-mTHPP was shown to be noncytotoxic since viability of cells cultured for 24 h in the presence of the nanoconjugate (100 μg/mL) was 78%. Considering the enhanced antibacterial activity and the absence of cytotoxic effect, it is possible to consider the ND-mTHPP nanoconjugate as promising platform for application in antimicrobial photodynamic therapy (aPDT). In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Computed Properties of C7H6O2
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