Roy, Niloy’s team published research in Chemical Physics Letters in 2020 | CAS: 23828-92-4

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Roy, Niloy; Bomzan, Pranish; Nath Roy, Mahendra published an article in Chemical Physics Letters. The title of the article was 《Probing Host-Guest inclusion complexes of Ambroxol Hydrochloride with α- & β-Cyclodextrins by physicochemical contrivance subsequently optimized by molecular modeling simulations》.Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The author mentioned the following in the article:

Herein, we report the inclusion of AMB in cyclodextrins leading to host-guest assemblies. The inclusion complexes comprised of Ambroxol Hydrochloride (AMB) with α-cyclodextrin (αCD) and β-cyclodextrin (βCD) have been confirmed by exptl. (UV-vis titration, FTIR, ESI-MS, 1NMR, 2D-NMR) and computational studies (mol. docking, mol. mechanics calculation). The mol. docking studies demonstrate a better insight into geometry and inclusion mode of AMB inside αCD as well as βCD cavity. Formation of inclusion complexes with different cyclodextrins causes some structural changes of guest mols. during the encapsulation process confirmed by bond length, dihedral angle changes and dynamic simulations. In the experiment, the researchers used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Referemce:
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