Zhang, Feng; Niu, Yujie; Hong, Dacheng; Ye, Yilin; Hua, Yuhui; Ding, Shihao; Zhang, Yandong published an article on February 28 ,2021. The article was titled 《Synthetic studies towards atkamine》, and you may find the article in Chinese Chemical Letters.Application In Synthesis of 4,4-Diethoxybutan-1-amine The information in the text is summarized as follows:
Atkamine (I) is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists. We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5 + 2] annulation and an asym. Michael addition The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved. A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5 + 2] annulation. In the experiment, the researchers used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Application In Synthesis of 4,4-Diethoxybutan-1-amine)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application In Synthesis of 4,4-Diethoxybutan-1-amine
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