Synthetic Route of 616-29-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1 ,3-diaminopropan-2-ol (200mg, 2.22mmols) was dissolved in 20ml methanol and triethylamine (20ml) was added dropwise. Boc anhydride (3eq) was then added and heated at 50C for 20min and 1 hr at room temperature. This was monitored by TLC (9:1) DCM:methanol. After completion saturated solution of NaHCC was added (40ml) and extracted with ethyl acetate. The solvent was evaporated in vacuo and used in the next step without purification.
According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF LINCOLN; SINGH, Ishwar; TAYLOR, Edward; (137 pag.)WO2018/162922; (2018); A1;,
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