Efficient preparation of apically substituted diamondoid derivatives was written by Kahl, Paul; Tkachenko, Boryslav A.; Novikovsky, Anatoliy A.; Becker, Jonathan; Dahl, Jeremy E. P.; Carlson, Robert M. K.; Fokin, Andrey A.; Schreiner, Peter R.. And the article was included in Synthesis in 2014.HPLC of Formula: 60462-27-3 The following contents are mentioned in the article:
The authors present an effective three-step chromatog.-free sequence for the preparation of apical monohydroxy derivatives of diamantane, triamantane and [121]tetramantane from the corresponding bis-apical diols utilizing tert-butyldimethylsilyl chloride as the silylation agent. The procedure was successfully applied to the protection of several other aliphatic and aromatic diols. Addnl., 9-amino-4-diamantanecarboxylic acid, which has significant potential in medicinal and material sciences, was prepared by a Ritter reaction of 4,9-dihydroxydiamantane in trifluoroacetic acid. The synthesis of the target compounds was achieved using octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalene-3,7-diol (4,9-diamantanediol), decahydro-4,5,12-metheno-2,9,7-[1,2,3]propanetriylanthracene-2,7(1H,3H)-diol (9,15-triamantanediol) and tetradecahydro-1,5,7,11-ethanediylidene-3,5:9,11-dimethanochrysene-3,9-diol (6,13-tetramantanediol) as starting materials. The tilte compounds thus formed included octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalen-3(2H)-ol, dodecahydro-4,5,12-metheno-2,9,7-[1,2,3]propanetriylanthracen-2(1H)-ol, tetradecahydro-1,5,7,11-ethanediylidene-3,5:9,11-dimethanochrysen-3(4H)-ol. Other diols included bicyclo[2.2.2]octane-1,4-diol, Pentacyclo[4.2.0.02,5.03,8.04,7]octane-1,4-dimethanol (cubane derivative), 1,10-decanediol, 1,8-octanediol, 1,4-benzenediol, 2,6-naphthalenediol, [1,1′-binaphthalene]-2,2′-diol. 7-(Amino)octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalene-3(2H)-carboxylic acid [i.e., (amino)diamantanecarboxylic acid] was prepared This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3HPLC of Formula: 60462-27-3).
Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 60462-27-3
60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3